The dimensions of human fantasy life revealed here should, we think, have a liberating effect upon many persons who may find a greater degree of self-acceptance once they have understood what a complicated being is man and how many and varied are his ideas, imaginings and tendencies, in health as well as in sickness. We hope that equally beneficial will be this first detailed presentation of a Western-oriented, non-mystical phenomenology and approach to the direction of the psychedelic session.
Have a read of this on Erowid Vaults. However, there’s a lot of words and pages, so in brief: this is an account of 206 first-hand experiences of drug sessions and interviews with 214 volunteer subjects, psychotherapy patients, or those who have obtained and taken the drugs on their own. People were mainly tripping on LSD-25 and peyote.
Author: R.E.L. Masters & Jean Houston, Ph.D.
Ketamine appears to be the first medication to produce a rapid, although short-lasting, antidepressant response.
Pathophysiology of major depressive disorder (MDD) is not currently known, some suggest there’s something wrong with serotonin system, some that brain glutamate systems may be responsible. Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, has potential in treating MDD and has indeed shown the capacity to do so.There’s also been a paper showing that “Small-Dose Ketamine Improves the Postoperative State of
Depressed Patients”. Plus, as patients with symptoms of depression have increased postoperative pain, ketamine may be used as both analgesic and antidepressant.